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American History

A Surgeon With 300% Mortality Rate From a Single Operation and Other Historic Screwups

Robert Liston - Surgery
Dr. Robert Liston operating. Wellcome Images

24. Millions of Lives Saved Because of a Mistake

Alexander Fleming and the discovery of penicillin. Bacteria in Photos

One day in 1922, while battling a cold, Fleming transferred some of his snot to a Petri dish. A slob, he put it on his cluttered desk, then forgot it for a couple of weeks. When he finally remembered and examined it, the Petri dish was full of bacterial colonies. However, the microscope revealed that one area of snot was free of bacteria. Further examination revealed that it was due to the presence of an enzyme, which he called lysozyme, which had some antimicrobial properties. That laid the groundwork for his discovery of penicillin.

In 1928, Fleming, still a lab slob, left an uncovered Petri dish next to an open window, where it became contaminated with fungus spores. When he checked it under the microscope, Fleming discovered that the bacteria near the fungus were dying. He managed to isolate the fungus, and discovered that it was effective against numerous pathogens that caused diseases such as pneumonia, meningitis, diphtheria,  scarlet fever, gonorrhea, and many more. Thus, penicillin was discovered. As Fleming put it: “I did not discover penicillin. Nature did that. I only discovered it by accident“.

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A lifelong history buff, I developed a particular passion for WW2 history as a child, when I spent hours listening to my grandfather, enraptured, as he recounted his wartime experiences in the British East African Campaign and with the British 8th Army in North Africa.

I graduated with a history BA from George Mason University, then went on to get a JD from the University of Virginia School of Law. After lawyering for a decade, I moved to sunny Rio de Janeiro and a less demanding career, opening a tourism agency in Copacabana.

A big chunk of my free time is spent blogging (you can follow me on Quora https://www.quora.com/profile/Khalid-Elhassan ) or freelance writing, mostly about my favorite subject, history.

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