8. Medical student allowed patients with Yellow Fever to vomit all over him – only so he could prove his theory right. Unfortunately, his theory was wrong.
Stubbins Ffirth, a trainee doctor in Philadelphia during the early 19th century theorized that yellow fever was not contagious, believing that the drop in cases during winter showed that it was more likely a result of the heat and stresses of the summer months. And he went further than most scientists in history to prove his theory right. He started his experiments by making small incisions on his arms and pouring “fresh black vomit” obtained from a yellow-fever patient into the cuts. Next he dribbled some vomit in his eyes. He fried some up on a skillet and inhaled the fumes.
After he fashioned some vomit into a pill and swallowed it, he decided to drink entire glasses of pure, undiluted black vomit. And still he didn’t get sick. Ffirth rounded out his experiment by liberally smearing himself with other yellow-fever tainted fluids: blood, saliva, perspiration, and urine. Healthy as ever, he declared his theory proven. Unfortunately, he was wrong. Yellow fever is very contagious, but it requires direct transmission into the blood stream, usually by a mosquito, to cause infection. But considering all Ffirth did to infect himself, it is a bit of a miracle he didn’t die from yellow fever.
7. Scientist performed an exchange blood transfusion between himself and a Thrombocytopenic patient to discover the immune basis of idiopathic Thrombocytopenic Purpura.
The infamous Harrington-Hollingsworth experiment was an experiment that established the autoimmune nature of the blood disorder immune thrombocytopenic purpura. The experiment was undertaken in 1950 by physician William J. Harrington and James W. Hollingsworth, who postulated that in patients with idiopathic thrombocytopenic purpura (ITP), it was a blood factor that caused the destruction of platelets. To test this hypothesis, Harrington received 500 ml of blood from a patient with ITP. Within three hours, his platelets dropped to dangerously low levels and he experienced a seizure. His platelet count remained extremely low for four days, finally returning to normal levels by the fifth day.
Bone marrow biopsy from Harrington’s sternum demonstrated normal megakaryocytes, the cells necessary for platelet production. Subsequently the experiment was repeated on all suitable staff members at the Barnes-Jewish Hospital. All subjects developed low platelet counts within three hours, and all recovered after a period of several days. Contemporary scientists consider the Harrington-Hollingsworth experiment a landmark in the understanding of ITP’s pathophysiology as it changed the meaning of the “I” in ITP from idiopathic to immune, but “immune” in this case means “autoimmune,” because the antibodies bind to and cause the destruction of the patient’s own platelets.
6. Surgeon investigated if Cancer was contagious by surgically inserting a piece of Cancerous lymph node from a patient with Cancer of the lip under his skin.
You may have heard of Nicholas Senn being the “father” of the Association of Military Surgeons of the United States, even though the man was Swiss in reality. He was born in Sevelen, Switzerland and emigrated to the United States with his family in 1852 when he was eight years old, settling in Ashford, Wisconsin. Nonetheless, Senn grew up becoming an American patriot who served as the president of the American Medical Association in 1897-98 and as chief surgeon of the Sixth Army Corps in 1898, seeing service in Cuba during the Spanish-American War. His contributions to medicine, however, are those that made him stand out.
He is credited with pioneering work on the pancreas and the intestinal tract and he was among the first to use the then unpredictable x-rays in the treatment of leukemia. His many experiments relating to the reason for infection resulting from surgery led to surgical improvements practiced by all surgeons. In 1901, he examined whether cancer was contagious. He surgically inserted under his skin a piece of cancerous lymph node from a patient with cancer of the lip. After two weeks, the transplant started to fade and Senn concluded that cancer is not contagious.
5. Medical student infected himself with the disease of a patient and died a few weeks later.
Daniel Alcides Carrion was a Peruvian medical student after whom Carrion’s disease is named. During his school excursions as a student, Carrion met several people with verrucous skin eruptions and caught an interest in the disease that was later named after him. From 1881 he conducted extensive research on “Oroya fever”, including clinical studies at the Dos de Mayo hospital in Lima. Carrion recognized that the disease was endemic, but not contagious. In order to find out whether the disease could be inoculated and to study its clinical course, Carrion decided to conduct an experiment on himself.
On August 27, 1885, Carrion took blood from a 14 year old boy that carried the disease. As Carrion had trouble inoculating himself, friends took the lancet and made four inoculations, two in each of Carrion’s arms. He experienced the first symptoms of the disease on September 17, and by September 26 he was too ill to make his own notes, which were continued by his friends attending him at the bedside. Carrion’s condition rapidly deteriorated and on October 5 he eventually died. Soon after his death from the disease, a fellow student who had assisted in the experiment was arrested for his “murder,” but later released.
4. Romanian Microbiologist injected himself with bacteria from rabbits suffering from Syphilis and prayed to be right about his medical theories.
Undoubtedly one of the most significant figures in virology and immunology – especially in the study of poliomyelitis and syphilis – Constantin Levaditi was accepted in 1900 to work in Dr. Metchnikoff’s team at the Pasteur Institute in Paris. He eventually became head of the laboratory of the Pasteur Institute for over 20 years, earned several honors and published more than 1,200 notes, articles, and monographs during his decorated career. He dominated the study of syphilis in his time and introduced new techniques in serology, such as using the silver-salt staining method in the livers of newborn congenital syphilitics.
He demonstrated that to supplement the Wassermann-Bordet reaction (an antibody test for syphilis), a normal liver could be used for diagnosis, thus pioneering the study of antigens. With his colleagues he applied bismuth therapy to syphilis, and achieved results with metallotherapy. When his opponents challenged his methods and theories, he didn’t hesitate to inject himself with infected bacteria from rabbits suffering from syphilis only so he could prove them wrong. Fortunately, he did not contract the disease after his bold experiment.
3. Surgeon safely removed his own appendix while under local anesthetic at the age of 60.
Even though there have been quite a few surgeons operating on themselves throughout the years, in most cases this was the result of emergency rather than self-experiment. There’s a bright exception to this rule though. The first surgeon to conduct a self-operation (as part of an experiment), was American surgeon Evan O’Neill Kane in 1921. In his illustrious thirty-seven-year medical career, Dr. O’Neill Kane had performed nearly four thousand appendectomies, so this surgery would be nothing new to the experienced surgeon.
However, there was a twist: he didn’t have to operate himself, but instead he decided to do so as part of his movement against the excessive use of general anesthetic at the time. During the procedure, Dr. O’Neil only complained of a minor discomfort. Once he was done with the procedure, he was taken into post-op and was placed in a hospital ward. He recovered quickly and was discharged two days later. Dr. O’Neil had proven his theory that local anesthesia was a viable alternative, and operated on himself again at the age of 70 to repair a hernia.
2. Air Force medical doctor volunteered to be used as “Human Rocket” in order to study the human body’s tolerance to Aircraft Crash Forces.
There’s a good chance that you know him as the “human rocket” or the “the fastest man on earth.” Colonel John Paul Stapp was an American career U.S. Air Force officer, flight surgeon, physician, biophysicist, and pioneer in studying the effects of acceleration and deceleration forces on humans who made history for his bold self-experiments. Stapp accelerated in 5 seconds from a standstill to 632 miles an hour, and then decelerated to a dead stop in 1.4 seconds, subjecting him to pressures 40 times the pull of gravity. From 1947 to 1955, he participated in 28 more such experiments and broke all kinds of land and deceleration records.
These tests investigated the effects of acceleration, G-force, deceleration, and wind blast on humans. Stapp suffered broken bones and retinal hemorrhages, but suffered no permanent damage. Stapp also became an early advocate of seatbelts and shoulder harnesses in cars. He created an automobile test facility and conducted the first-ever crash tests with dummies; tests that are still used for crash safety ratings. Despite taking part in so many dangerous tests, Stapp died peacefully at his home in Alamogordo, New Mexico, at the age of 89.
1. The doctor who kept notes while dying from a cocaine overdose.
In what may be the greatest demonstration of altruism in medical history, Edwin Katskee literally gave his life to test the effects of cocaine to its addicts. The main difference of Dr. Katskee with any other scientist included in this list is that he knew his death was inevitable when he was injecting a deadly dose of cocaine into his veins. He didn’t seek help, but instead he tried to calmly record his observations as the drug took effect. He described what he had done as a “scientific experiment with death.” It’s important to note, however, that by the year of his death (1936), Dr. Katskee’s life began to fall apart.
In August of that year, his wife filed for divorce citing “extreme cruelty” and asked for custody of their two young children. Not long afterward, Dr. Katskee experienced a series of health crises, including gall bladder surgery and spending time in a sanitarium. Two months later, his uncle committed suicide following a nervous breakdown. Suicide or not, the fact remains that Dr. Katskee sacrificed his life in order to find out what the addicts experience themselves during an overdose. Unfortunately, his notes as scattered as they were and without proper timekeeping, did not prove useful for his colleagues.
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